A sign urges the release of the monkeypox vaccine during a protest in San Francisco, July 18, 2022. The mayor of San Francisco announced a legal state of emergency Thursday, July 28, 2022, over the growing number of monkeypox cases. Public health officials warn that moves by rich countries to buy large quantities of monkeypox vaccine, while declining to share doses with Africa, could leave millions of people unprotected against a more dangerous version of the disease and risk continued spillovers of the virus into humans. (AP Photo/Haven Daley, File)